Disease overview

Nasal Parakeratosis is a genetic disease that affects specialized cells of the nose, which results in crusting and cracking over the nasal area. Affected dogs are otherwise healthy.

Gene name

SUV39H2

Inheritance

Autosomal recessive

Signs and symptoms

Signs typically appear around 6-12 months of age. These signs include dry, rough crusts on the surface and edge of the nose that are brown or gray in color. Fluid may accumulate in the cracks. Depending on severity, the cracks may be painful and/or lead to bacterial infections.

How is it diagnosed

A veterinarian will review health history, conduct a thorough exam, and note any clinical signs. A skin biopsy may be needed to support a diagnosis. Genetic testing assists veterinarians with diagnosis and helps breeders identify affected and carrier dogs.

Breeds at higher risk

Labrador Retriever, Labradoodle, Greyhound

Citations

Goldstein O, Kukekova AV, Aguirre GD, Acland GM. Exonic SINE insertion in STK38L causes canine early retinal degeneration (erd). Genomics. 2010 Dec;96(6):362-8. doi: 10.1016/j.ygeno.2010.09.003. Epub 2010 Sep 29. PMID: 20887780; PMCID: PMC2996878.

Disclaimer

Disease diagnosis and treatment should always be performed by a veterinarian. The following information is for educational purposes only.